Glycoengineered Outer Membrane Vesicles: A Novel Platform for Bacterial Vaccines.

ABSTRACT: The World Health Organization has indicated that we are entering into a post-antibiotic era in which infections that were routinely and successfully treated with antibiotics can now be lethal due to the global dissemination of multidrug resistant strains. Conjugate vaccines are an effective way to create a long-lasting immune response against bacteria. However, these vaccines present many drawbacks such as slow development, high price, and batch-to-batch inconsistencies. Alternate approaches for vaccine development are urgently needed. Here we present a new vaccine consisting of glycoengineered outer membrane vesicles (geOMVs). This platform exploits the fact that the initial steps in the biosynthesis of most bacterial glycans are similar. Therefore, it is possible to easily engineer non-p

SUBMITTER: Price NL 

PROVIDER: S-EPMC4840304 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature