Systematic Analysis of Adverse Event Reports for Sex Differences in Adverse Drug Events.

ABSTRACT: Increasing evidence has shown that sex differences exist in Adverse Drug Events (ADEs). Identifying those sex differences in ADEs could reduce the experience of ADEs for patients and could be conducive to the development of personalized medicine. In this study, we analyzed a normalized US Food and Drug Administration Adverse Event Reporting System (FAERS). Chi-squared test was conducted to discover which treatment regimens or drugs had sex differences in adverse events. Moreover, reporting odds ratio (ROR) and P value were calculated to quantify the signals of sex differences for specific drug-event combinations. Logistic regression was applied to remove the confounding effect from the baseline sex difference of the events. We detected among 668 drugs of the most frequent 20 treatment regi

SUBMITTER: Yu Y 

PROVIDER: S-EPMC4840306 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature