Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes.

ABSTRACT: Rodent-based studies have shown that the membrane properties of oligodendrocytes play prominent roles in their physiology and shift markedly during their maturation from the oligodendrocyte precursor cell (OPC) stage. However, the conservation of these properties and maturation processes in human oligodendrocytes remains unknown, despite their dysfunction being implicated in human neurodegenerative diseases such as multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). Here, we have defined the membrane properties of human oligodendrocytes derived from pluripotent stem cells as they mature from the OPC stage, and have identified strong conservation of maturation-specific physiological characteristics reported in rodent systems. We find that as human oligodendrocytes develop and e

SUBMITTER: Livesey MR 

PROVIDER: S-EPMC4840312 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature