The visual perception of natural motion: abnormal task-related neural activity in DYT1 dystonia.

ABSTRACT: Although primary dystonia is defined by its characteristic motor manifestations, non-motor signs and symptoms have increasingly been recognized in this disorder. Recent neuroimaging studies have related the motor features of primary dystonia to connectivity changes in cerebello-thalamo-cortical pathways. It is not known, however, whether the non-motor manifestations of the disorder are associated with similar circuit abnormalities. To explore this possibility, we used functional magnetic resonance imaging to study primary dystonia and healthy volunteer subjects while they performed a motion perception task in which elliptical target trajectories were visually tracked on a computer screen. Prior functional magnetic resonance imaging studies of healthy subjects performing this task have reve

SUBMITTER: Sako W 

PROVIDER: S-EPMC4840548 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature