Proteogenomics of Candida tropicalis--An Opportunistic Pathogen with Importance for Global Health.

ABSTRACT: The frequency of Candida infections is currently rising, and thus adversely impacting global health. The situation is exacerbated by azole resistance developed by fungal pathogens. Candida tropicalis is an opportunistic pathogen that causes candidiasis, for example, in immune-compromised individuals, cancer patients, and those who undergo organ transplantation. It is a member of the non-albicans group of Candida that are known to be azole-resistant, and is frequently seen in individuals being treated for cancers, HIV-infection, and those who underwent bone marrow transplantation. Although the genome of C. tropicalis was sequenced in 2009, the genome annotation has not been supported by experimental validation. In the present study, we have carried out proteomics profiling of C. tropicalis

SUBMITTER: Datta KK 

PROVIDER: S-EPMC4840825 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature