Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors.

ABSTRACT: Primary prostate cancer almost always has a luminal phenotype. However, little is known about the stem/progenitor properties of transformed cells within tumors. Using the aggressive Pten/Tp53-null mouse model of prostate cancer, we show that two classes of luminal progenitors exist within a tumor. Not only did tumors contain previously described multipotent progenitors, but also a major population of committed luminal progenitors. Luminal cells, sorted directly from tumors or grown as organoids, initiated tumors of adenocarcinoma or multilineage histological phenotypes, which is consistent with luminal and multipotent differentiation potentials, respectively. Moreover, using organoids we show that the ability of luminal-committed progenitors to self-renew is a tumor-specific property, abse

SUBMITTER: Agarwal S 

PROVIDER: S-EPMC4840850 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature