Association between vitamin D status and age-related macular degeneration by genetic risk.

ABSTRACT:

Importance

Deficient 25-hydroxyvitamin D (25[OH]D) concentrations have been associated with increased odds of age-related macular degeneration (AMD).

Objective

To examine whether this association is modified by genetic risk for AMD and whether there is an association between AMD and single-nucleotide polymorphisms of genes involved in vitamin D transport, metabolism, and genomic function.

Design, setting, and participants

Postmenopausal women (N = 913) who were participants of the Carotenoids in Age-Related Eye Disease Study (CAREDS) (aged 54 to <75 years) with available serum 25(OH)D concentrations (assessed October 1, 1993, to December 31, 1998), genetic data, and measures of AMD (n = 142) assessed at CAREDS baseline from May 14, 2001, through January 31, 2004, were

SUBMITTER: Millen AE 

PROVIDER: S-EPMC4841267 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature