Effects of Genetic Loci Associated with Central Obesity on Adipocyte Lipolysis.

ABSTRACT:

Objectives

Numerous genetic loci have been associated with measures of central fat accumulation, such as waist-to-hip ratio adjusted for body mass index (WHRadjBMI). However the mechanisms by which genetic variations influence obesity remain largely elusive. Lipolysis is a key process for regulation of lipid storage in adipocytes, thus is implicated in obesity and its metabolic complications. Here, genetic variants at 36 WHRadjBMI-associated loci were examined for their influence on abdominal subcutaneous adipocyte lipolysis.

Subjects and methods

Fasting subcutaneous adipose tissue biopsies were collected from 789 volunteers (587 women and 202 men, body mass index (BMI) range 17.7-62.3 kg/m2). We quantified subcutaneous adipocyte lipolysis, both spontaneous and stimulated by

SUBMITTER: Strawbridge RJ 

PROVIDER: S-EPMC4841524 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature