Characteristics of Resting-State Functional Connectivity in HIV-Associated Neurocognitive Disorder.

ABSTRACT:

Background

HIV-associated neurocognitive disorder (HAND) can occur in patients without prior AIDS defining illness and can be debilitating. This study aimed to evaluate the difference in the patterns of intrinsic brain activity between patients with or without HAND for deepening our understanding of HAND.

Methods

We evaluated 24 HIV-infected individuals, 12 with previously diagnosed HAND and 12 previously diagnosed without HAND, and 11 seronegative individuals. These individuals then underwent repeat NP testing and a functional brain MRI scan. For functional MRI analysis, seed-based analysis with bilateral precuneus cortex seed was applied.

Results

Among the 12 individuals with previously diagnosed HAND, 3 showed improvement of their neurocognitive function and 1 was

SUBMITTER: Ann HW 

PROVIDER: S-EPMC4841538 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature