Widespread inflammation in CLIPPERS syndrome indicated by autopsy and ultra-high-field 7T MRI.

ABSTRACT:

Objective

To examine if there is widespread inflammation in the brain of patients with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome by using histology and ultra-high-field MRI at 7.0T.

Methods

We performed a detailed neuropathologic examination in 4 cases, including 1 autopsy case, and studied 2 additional patients by MRI at 7.0T to examine (1) extension of inflammation to areas appearing normal on 3.0T MRI, (2) potential advantages of 7.0T MRI compared to 3.0T MRI in reflecting widespread inflammation, perivascular pathology, and axonal damage, and (3) the possibility of lymphoma.

Results

In the autopsy case, perivascular inflammation dominated by CD4+ T cells was not only detected in the brainstem

SUBMITTER: Blaabjerg M 

PROVIDER: S-EPMC4841643 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature