Interarm differences in systolic blood pressure and the risk of dementia and subclinical brain injury.

ABSTRACT:

Introduction

This study examined whether interarm differences in systolic blood pressure (IDSBP) ≥10 mm Hg were associated with the risk of incident dementia and subclinical brain injury.

Methods

Between 1992 and 1998, 2063 participants of the Framingham Heart Study underwent assessment of IDSBP with results related to the 10-year risk of incident dementia including clinically characterized Alzheimer's disease. Secondary outcomes included markers of subclinical brain injury on magnetic resonance imaging.

Results

High IDSBP were associated with a greater risk of incident dementia (hazard ratio [HR] 1.92; 95% confidence interval [CI], 1.09-3.40) and Alzheimer's disease (HR, 2.32; 95% CI, 1.29-4.18), but only in those who carried an apolipoprotein E (APOE) ε4 allele. IDS

SUBMITTER: Pase MP 

PROVIDER: S-EPMC4841714 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature