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A cationic gadolinium contrast agent for magnetic resonance imaging of cartilage.

ABSTRACT: A new cationic gadolinium contrast agent is reported for delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC). The agent partitions into the glycosaminoglycan rich matrix of articular cartilage, based on Donnan equilibrium theory, and its use enables imaging of the human cadaveric metacarpal phalangeal joint.

SUBMITTER: Freedman JD 

PROVIDER: S-EPMC4841792 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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A cationic gadolinium contrast agent for magnetic resonance imaging of cartilage.

Freedman Jonathan D JD   Lusic Hrvoje H   Wiewiorski Martin M   Farley Michelle M   Snyder Brian D BD   Grinstaff Mark W MW  

Chemical communications (Cambridge, England) 20150601 56

A new cationic gadolinium contrast agent is reported for delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC). The agent partitions into the glycosaminoglycan rich matrix of articular cartilage, based on Donnan equilibrium theory, and its use enables imaging of the human cadaveric metacarpal phalangeal joint. ...[more]

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