Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome.

ABSTRACT:

Background

Increased maternal body mass index (BMI) is a robust risk factor for later pediatric obesity. Accumulating evidence suggests that human milk (HM) may attenuate the transfer of obesity from mother to offspring, potentially through its effects on early development of the infant microbiome.

Objectives

Our objective was to identify early differences in intestinal microbiota in a cohort of breastfeeding infants born to obese compared with normal-weight (NW) mothers. We also investigated relations between HM hormones (leptin and insulin) and both the taxonomic and functional potentials of the infant microbiome.

Design

Clinical data and infant stool and fasting HM samples were collected from 18 NW [prepregnancy BMI (in kg/m(2)) <24.0] and 12 obese (prepregnancy BM

SUBMITTER: Lemas DJ 

PROVIDER: S-EPMC4841936 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature