Ontology highlight
ABSTRACT:
SUBMITTER: Opi DH
PROVIDER: S-EPMC4842007 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Opi D H DH Uyoga S S Orori E N EN Williams T N TN Rowe J A JA
Genes and immunity 20160204 3
Both the invasion of red blood cells (RBCs) by Plasmodium falciparum parasites and the sequestration of parasite-infected RBCs in the microvasculature are mediated in part by complement receptor one (CR1). RBC surface CR1 level can vary between individuals by more than 20-fold and may be associated with the risk of severe malaria. The factors that influence RBC CR1 level variation are poorly understood, particularly in African populations. We studied 3535 child residents of a malaria-endemic reg ...[more]