Prospective comparison of magnetic resonance imaging to transient elastography and serum markers for liver fibrosis detection.

ABSTRACT:

Background & aims

Establishing accurate non-invasive methods of liver fibrosis quantification remains a major unmet need. Here, we assessed the diagnostic value of a multiparametric magnetic resonance imaging (MRI) protocol including diffusion-weighted imaging (DWI), dynamic contrast-enhanced (DCE)-MRI and magnetic resonance elastography (MRE) in comparison with transient elastography (TE) and blood tests [including ELF (Enhanced Liver Fibrosis) and APRI] for liver fibrosis detection.

Methods

In this single centre cross-sectional study, we prospectively enrolled 60 subjects with liver disease who underwent multiparametric MRI (DWI, DCE-MRI and MRE), TE and blood tests. Correlation was assessed between non-invasive modalities and histopathologic findings including stage, grad

SUBMITTER: Dyvorne HA 

PROVIDER: S-EPMC4842106 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature