Infliximab Dosing Strategies and Predicted Trough Exposure in Children With Crohn Disease.

ABSTRACT:

Objectives

Standard infliximab maintenance dosing of 5 mg/kg every 8 weeks may be inadequate to consistently achieve sufficient drug exposure to minimize loss of response or treatment failure in pediatric Crohn disease (CD). We aimed to determine the predicted infliximab trough concentrations in children with CD during maintenance therapy and the percentage of patients achieving target trough concentration >3 μg/mL.

Methods

A Monte Carlo simulation analysis was constructed using a published population pharmacokinetic model based on data from 112 children in the REACH trial. We assessed maintenance dosing strategies of 5, 7.5, and 10 mg/kg at dosing intervals of every 4, 6, and 8 weeks for children that differed by age, weight, albumin level, and concomitant immunomodulator t

SUBMITTER: Frymoyer A 

PROVIDER: S-EPMC4842177 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature