Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study.

ABSTRACT:

Background

Asthma is a biologically heterogeneous disease and development of novel therapeutics requires understanding of pathophysiologic phenotypes. There is uncertainty regarding the stability of clinical characteristics and biomarkers in asthma over time. This report presents the longitudinal stability over 12 months of clinical characteristics and clinically accessible biomarkers from ADEPT.

Methods

Mild, moderate, and severe asthma subjects were assessed at 5 visits over 12 months. Assessments included patient questionnaires, spirometry, bronchodilator reversibility, fractional exhaled nitric oxide (FENO), and biomarkers measured in induced sputum.

Results

Mild (n = 52), moderate (n = 55), and severe (n = 51) asthma cohorts were enrolled from North America and W

SUBMITTER: Silkoff PE 

PROVIDER: S-EPMC4842260 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature