Immunomodulation by mesenchymal stem cells in treating human autoimmune disease-associated lung fibrosis.

ABSTRACT:

Background

Interstitial pneumonia in connective tissue diseases (CTD-IP) featuring inflammation and fibrosis is a leading cause of death in CTD-IP patients. The related autoimmune lung injury and disturbed self-healing process make conventional anti-inflammatory drugs ineffective. Equipped with unique immunoregulatory and regenerative properties, mesenchymal stem cells (MSCs) may represent a promising therapeutic agent in CTD-IP. In this study, we aim to define the immunopathology involved in pulmonary exacerbation during autoimmunity and to determine the potential of MSCs in correcting these disorders.

Methods

Lung and blood specimens, bronchoalveolar lavage fluid cells collected from CTD-IP patients, and human primary lung fibroblasts (HLFs) from patients pathologically di

SUBMITTER: Liu M 

PROVIDER: S-EPMC4842299 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature