Ultrasmall dual-modality silica nanoparticle drug conjugates: Design, synthesis, and characterization.

ABSTRACT: The physicochemical design and synthesis of effective cancer-directed and particle-based nanotherapeutic imaging agents remains a challenging task. Of critical importance is the ability to demonstrate maximum delivery, retention, and treatment efficacy for platforms designed to deposit their cargo at sites of disease without attendant dose-limiting toxicity. In this work, we describe dual-modality nanoparticle drug conjugates (NDCs) which utilize protease sensitive linkers to attached drug compounds and imaging labels to a clinically translated class of ultrasmall silica nanoparticle (C' dots). We describe the synthesis and characterization of these linker-drug constructs. Linkers incorporating dipeptide enzyme substrates are attached to analogs of a prototypical epidermal growth factor re

SUBMITTER: Yoo B 

PROVIDER: S-EPMC4842310 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature