AB160. Association of nineteen polymorphisms from seven DNA repair genes and the risk for bladder cancer in China

ABSTRACT:

Objective

Balance of DNA damage and proper repair plays an important role in progression of bladder cancer. Here we aimed to assess the associations of nineteen polymorphisms from seven DNA repair-associated genes (PRAP1, OGG1, APEX1, MUTYH, XRCC1, XRCC2 and XRCC3) and their interactions with bladder cancer in a Han Chinese population.

Methods

A case-control study including 227 bladder cancer patients and 260 healthy controls was conducted. A chip-based TaqMan genotyping was performed for the candidate genes.

Results

APEX1 rs3136817, MUTYH rs3219493, three SNPs (rs3213356, rs2023614 and rs1799782) in XRCC1, and two SNPs (rs1799794 and rs861530) in XRCC3 showed significant associations with the risk of bladder cancer. After the Bonferroni correction, these associa

SUBMITTER:  

PROVIDER: S-EPMC4842511 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature