AB126. Association between FOX03A gene polymorphisms and human longevity: a meta-analysis

ABSTRACT:

Objective

Numerous studies have shown associations between the FOX03A gene, encoding the forkhead box 03 transcription factor, and human or specifically male longevity. However, the associations of specific FOX03A polymorphisms with longevity remain inconclusive. We performed a meta-analysis of existing studies to clarify these potential associations.

Methods

A comprehensive search was conducted to identify studies of FOX03A gene polymorphisms and longevity. Pooled odds ratios (ORs) and 95% confidence intervals (Cls) were calculated by comparing the minor and major alleles.

Results

A total of seven articles reporting associations of FOX03A polymorphisms with longevity were identified and included in this meta-analysis. These comprised 11 independent studies with

SUBMITTER:  

PROVIDER: S-EPMC4842737 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature