Antinociceptive effects of sinomenine in a rat model of postoperative pain.

ABSTRACT:

Background and purpose

This study examined the antinociceptive effects of sinomenine in a rat model of postoperative pain.

Experimental approach

Male and female rats were subjected to a surgical incision in the right hind paw, and the von Frey filament test was used to measure mechanical hypersensitivity after drug or vehicle treatment (p.o. or i.p.). Rats were treated daily with sinomenine before or after the surgery and the AUCs of the antinociceptive effects measured during a 4 h period were calculated to determine the ED50 values of sinomenine. The anti-hyperalgesic effects of different doses of a combination of sinomenine and acetaminophen (paracetamol) were assessed in another group of rats. Dose combinations were determined by using a fixed ratio dose-addition analysi

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC4842916 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature