Insulin Sensitivity and β-Cell Function Improve after Gastric Bypass in Severely Obese Adolescents.

ABSTRACT:

Objective

To test the hypothesis that insulin secretion and insulin sensitivity would be improved in adolescents after Roux-en-Y gastric bypass (RYGB).

Study design

A longitudinal study of 22 adolescents and young adults without diabetes undergoing laparoscopic RYGB (mean age 17.1 ± 1.42 years; range 14.5-20.1; male/female 8/14; Non-Hispanic White/African American 17/5) was conducted. Intravenous glucose tolerance tests were done to obtain insulin sensitivity (insulin sensitivity index), insulin secretion (acute insulin response to glucose ), and the disposition index as primary outcome variables. These variables were compared over the 1 year of observation using linear mixed modeling.

Results

In the 1-year following surgery, body mass index fell by 38% from a mean of

SUBMITTER: Inge TH 

PROVIDER: S-EPMC4843108 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature