Periodontal disease and risk of all cancers among male never smokers: an updated analysis of the Health Professionals Follow-up Study.

ABSTRACT:

Background

Periodontal disease has a direct impact on the immune response and has been linked to several chronic diseases, including atherosclerosis and stroke. Few studies have examined the association between periodontal disease and cancer.

Patients and methods

A total of 19 933 men reported being never smokers (of cigarette, pipes or cigars) in the Health Professionals' Follow-up Study. Periodontal disease status and teeth number were self-reported at baseline and during follow-up. All cancers were ascertained during 26 years of follow-up. Cox's proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) adjusting for risk factors.

Results

A 13% increase in total cancer was observed among men reporting periodontitis a

SUBMITTER: Michaud DS 

PROVIDER: S-EPMC4843185 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature