Patient-reported quality-of-life analysis of radium-223 dichloride from the phase III ALSYMPCA study.

ABSTRACT:

Background

Radium-223 dichloride (radium-223), a first-in-class α-emitting radiopharmaceutical, is recommended in both pre- and post-docetaxel settings in patients with castration-resistant prostate cancer (CRPC) and symptomatic bone metastases based on overall survival benefit demonstrated in the phase III ALSYMPCA study. ALSYMPCA included prospective measurements of health-related quality of life (QOL) using two validated instruments: the general EuroQoL 5D (EQ-5D) and the disease-specific Functional Assessment of Cancer Therapy-Prostate (FACT-P).

Patients and methods

Analyses were conducted to determine treatment effects of radium-223 plus standard of care (SOC) versus placebo plus SOC on QOL using FACT-P and EQ-5D. Outcomes assessed were percentage of patients experienci

SUBMITTER: Nilsson S 

PROVIDER: S-EPMC4843190 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature