Potential impact of spatially targeted adult tuberculosis vaccine in Gujarat, India.

ABSTRACT: Some of the most promising vaccines in the pipeline for tuberculosis (TB) target adolescents and adults. Unlike for childhood vaccines, high-coverage population-wide vaccination is significantly more challenging for adult vaccines. Here, we aimed to estimate the impact of vaccine delivery strategies that were targeted to high-incidence geographical 'hotspots' compared with randomly allocated vaccination. We developed a spatially explicit mathematical model of TB transmission that distinguished these hotspots from the general population. We evaluated the impact of targeted and untargeted vaccine delivery strategies in India--a country that bears more than 25% of global TB burden, and may be a potential early adopter of the vaccine. We collected TB notification data and conducted a demonstra

SUBMITTER: Shrestha S 

PROVIDER: S-EPMC4843669 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature