Polymorphisms in DNA repair genes, hair dye use, and the risk of non-Hodgkin lymphoma.

ABSTRACT:

Purpose

Genetic polymorphisms in DNA repair genes and hair dye use may both have a role in the development of non-Hodgkin lymphoma (NHL). We aimed to examine the interaction between variants in DNA repair genes and hair dye use with risk of NHL in a population-based case-control study of Connecticut women.

Methods

We examined 24 single nucleotide polymorphisms in 16 DNA repair genes among 518 NHL cases and 597 controls and evaluated the associations between hair dye use and risk of overall NHL and common NHL subtypes, stratified by genotype, using unconditional logistic regression.

Results

Women who used hair dye before 1980 had a significantly increased risk of NHL, particularly for the follicular lymphoma (FL) subtype, but not for diffuse large B-cell lymphoma. The

SUBMITTER: Guo H 

PROVIDER: S-EPMC4843788 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature