Ontology highlight
ABSTRACT:
SUBMITTER: Schumacher MA
PROVIDER: S-EPMC4844061 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20150901 6252
Although recent studies have provided a wealth of information about archaeal biology, nothing is known about the molecular basis of DNA segregation in these organisms. Here, we unveil the machinery and assembly mechanism of the archaeal Sulfolobus pNOB8 partition system. This system uses three proteins: ParA; an atypical ParB adaptor; and a centromere-binding component, AspA. AspA utilizes a spreading mechanism to create a DNA superhelix onto which ParB assembles. This supercomplex links to the ...[more]