The Limited Utility of Multiunit Data in Differentiating Neuronal Population Activity.

ABSTRACT: To date, single neuron recordings remain the gold standard for monitoring the activity of neuronal populations. Since obtaining single neuron recordings is not always possible, high frequency or 'multiunit activity' (MUA) is often used as a surrogate. Although MUA recordings allow one to monitor the activity of a large number of neurons, they do not allow identification of specific neuronal subtypes, the knowledge of which is often critical for understanding electrophysiological processes. Here, we explored whether prior knowledge of the single unit waveform of specific neuron types is sufficient to permit the use of MUA to monitor and distinguish differential activity of individual neuron types. We used an experimental and modeling approach to determine if components of the MUA can monito

SUBMITTER: Keller CJ 

PROVIDER: S-EPMC4844128 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature