Comparative Risk Predictions of Second Cancers After Carbon-Ion Therapy Versus Proton Therapy.

ABSTRACT:

Purpose

This work proposes a theoretical framework that enables comparative risk predictions for second cancer incidence after particle beam therapy for different ion species for individual patients, accounting for differences in relative biological effectiveness (RBE) for the competing processes of tumor initiation and cell inactivation. Our working hypothesis was that use of carbon-ion therapy instead of proton therapy would show a difference in the predicted risk of second cancer incidence in the breast for a sample of Hodgkin lymphoma (HL) patients.

Methods and materials

We generated biologic treatment plans and calculated relative predicted risks of second cancer in the breast by using two proposed methods: a full model derived from the linear quadratic model and a simp

SUBMITTER: Eley JG 

PROVIDER: S-EPMC4844193 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature