Maternal immune activation induces GAD1 and GAD2 promoter remodeling in the offspring prefrontal cortex.

ABSTRACT: Maternal infection during pregnancy increases the risk of neurodevelopmental disorders in the offspring. In addition to its influence on other neuronal systems, this early-life environmental adversity has been shown to negatively affect cortical γ-aminobutyric acid (GABA) functions in adult life, including impaired prefrontal expression of enzymes required for GABA synthesis. The underlying molecular processes, however, remain largely unknown. In the present study, we explored whether epigenetic modifications represent a mechanism whereby maternal infection during pregnancy can induce such GABAergic impairments in the offspring. We used an established mouse model of prenatal immune challenge that is based on maternal treatment with the viral mimetic poly(I:C). We found that prenatal immune

SUBMITTER: Labouesse MA 

PROVIDER: S-EPMC4844233 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature