Obesity and overweight as CAE comorbidities and differential drug response modifiers.

ABSTRACT:

Objective

This study examined whether overweight and obesity are pretreatment comorbidities and predictors of short-term drug response in newly diagnosed untreated childhood absence epilepsy (CAE). We also examined whether dietary intake accounts for observed pretreatment body mass index (BMI) distribution.

Methods

Pretreatment height and weight were available for 445 of 446 participants in the NIH-funded CAE comparative effectiveness trial (NCT00088452). Twenty-four-hour dietary recalls were collected. Calculated BMI and dietary intake were standardized for age, sex, and race/ethnicity and compared to age-matched US population from the National Health and Nutrition Examination Survey (NHANES). Logistic regression models tested BMI as a predictor of treatment response. Pharm

SUBMITTER: Arya R 

PROVIDER: S-EPMC4844235 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature