Bone biology-related gingival transcriptome in ageing and periodontitis in non-human primates.

ABSTRACT:

Aim

Cellular and molecular immunoinflammatory changes in gingival tissues drive alveolar bone loss in periodontitis. Since ageing is a risk factor for periodontitis, we sought to identify age-related gingival transcriptome changes associated with bone metabolism in both healthy and in naturally occurring periodontitis.

Materials and methods

Adult (12-16 years) and aged (18-23 years) non-human primates (M. mulatta) (n = 24) were grouped into healthy and periodontitis. Gingival tissue samples were obtained and subjected to microarray analysis using the Gene Chip Macaque Genome Array. Gene expression profiles involved in osteoclast/osteoblast proliferation, adhesion and function were evaluated and compared across and between the age groups. QPCR was also performed on selected g

SUBMITTER: Pandruvada SN 

PROVIDER: S-EPMC4844783 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature