Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission.

ABSTRACT: Repeated treatments with praziquantel reduce schistosomiasis prevalence and morbidity, but transmission persists and populations often recover within a few years. To identify factors associated with persistence, we surveyed and treated all identified Schistosoma mansoni infections in two rural Brazilian communities (Jenipapo and Volta do Rio) in 2009, 2012 and 2013. Eggs were collected from all infected individuals and genotyped with 11 microsatellite markers to evaluate parasite differentiation and diversity. After successive rounds of community-wide treatment, prevalence decreased from 45% to 24% then 16%. Intensity of infection decreased by 57% over this period, and the number of eggs transmitted to the environment decreased by 92%. During all time periods the majority of eggs were excr

SUBMITTER: Barbosa LM 

PROVIDER: S-EPMC4844855 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature