Modeling Multisystem Physiological Dysregulation.

ABSTRACT:

Objectives

The purposes of this study were to compare the relative fit of two alternative factor models of allostatic load (AL) and physiological systems, and to test factor invariance across age and sex.

Methods

Data were from the Midlife in the United States II Biomarker Project, a large (n = 1255) multisite study of adults aged 34 to 84 years (56.8% women). Specifically, 23 biomarkers were included, representing seven physiological systems: metabolic lipids, metabolic glucose, blood pressure, parasympathetic nervous system, sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and inflammation. For factor invariance tests, age was categorized into three groups (≤45, 45-60, and >60 years).

Results

A bifactor model where biomarkers simultaneously load onto

SUBMITTER: Wiley JF 

PROVIDER: S-EPMC4844860 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature