A Systematic Analysis of Drosophila Regulatory Peptide Expression in Enteroendocrine Cells.

ABSTRACT: The digestive system is gaining interest as a major regulator of various functions including immune defense, nutrient accumulation, and regulation of feeding behavior, aside from its conventional function as a digestive organ. The Drosophila midgut epithelium is completely renewed every 1-2 weeks due to differentiation of pluripotent intestinal stem cells in the midgut. Intestinal stem cells constantly divide and differentiate into enterocytes that secrete digestive enzymes and absorb nutrients, or enteroendocrine cells that secrete regulatory peptides. Regulatory peptides have important roles in development and metabolism, but study has mainly focused on expression and functions in the nervous system, and not much is known about the roles in endocrine functions of enteroendocrine cells. W

SUBMITTER: Chen J 

PROVIDER: S-EPMC4844944 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature