North American ginseng influences adipocyte-macrophage crosstalk regulation of inflammatory gene expression.

ABSTRACT:

Background

Adipocyte-macrophage communication plays a critical role regulating white adipose tissue (WAT) inflammatory gene expression. Because WAT inflammation contributes to the development of metabolic diseases, there is significant interest in understanding how exogenous compounds regulate the adipocyte-macrophage crosstalk. An aqueous (AQ) extract of North American (NA) ginseng (Panax quinquefolius) was previously shown to have strong inflammo-regulatory properties in adipocytes. This study examined whether different ginseng extracts influence adipocyte-macrophage crosstalk, as well as WAT inflammatory gene expression.

Methods

The effects of AQ and ethanol (EtOH) ginseng extracts (5 μg/mL) on adipocyte and macrophage inflammatory gene expression were studied in 3T3-L1 a

SUBMITTER: Garbett J 

PROVIDER: S-EPMC4845049 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature