Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study.

ABSTRACT:

Background

While aspirin is a well-established and generally effective anti-platelet agent, considerable inter-individual variation in drug response exists, for which mechanisms are not completely understood. Metabolomics allows for extensive measurement of small molecules in biological samples, enabling detailed mapping of pathways involved in drug response.

Methods and results

We used a mass-spectrometry-based metabolomics platform to investigate the changes in the serum oxylipid metabolome induced by an aspirin intervention (14 days, 81 mg/day) in healthy subjects (n=156). We observed a global decrease in serum oxylipids in response to aspirin (25 metabolites decreased out of 30 measured) regardless of sex. This decrease was concomitant with a significant decrease in seru

SUBMITTER: Ellero-Simatos S 

PROVIDER: S-EPMC4845113 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature