Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity.

ABSTRACT: The naked mole-rat (NMR) is the longest-lived rodent and possesses several exceptional traits: marked cancer resistance, negligible senescence, prolonged genomic integrity, pronounced proteostasis, and a sustained health span. The underlying molecular mechanisms that contribute to these extraordinary attributes are currently under investigation to gain insights that may conceivably promote and extend human health span and lifespan. The ubiquitin-proteasome and autophagy-lysosomal systems play a vital role in eliminating cellular detritus to maintain proteostasis and have been previously shown to be more robust in NMRs when compared with shorter-lived rodents. Using a 2-D PAGE proteomics approach, differential expression and phosphorylation levels of proteins involved in proteostasis networ

SUBMITTER: Triplett JC 

PROVIDER: S-EPMC4845741 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature