Predictors of survival in coexistent hypersensitivity pneumonitis with autoimmune features.

ABSTRACT:

Background

Hypersensitivity pneumonitis (HP), an immune-mediated inflammatory interstitial lung disease (ILD), can result from exposure to several well-recognized antigens. Despite antigen avoidance, progressive pulmonary fibrosis and death can occur, suggesting that additional factors may contribute to disease activity. We hypothesized that the presence of autoimmunity might impact clinical course in patients with HP. In this study, we examined an HP cohort to identify those with HP and autoimmune features (HPAF), and determine its prevalence and outcomes.

Methods

The University of Chicago ILD registry was screened to identify patients with HP. Patients were characterized as HPAF if they had an autoimmune disease or features of autoimmunity, defined as the presence of speci

SUBMITTER: Adegunsoye A 

PROVIDER: S-EPMC4845760 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature