Integrated multiomics approach identifies calcium and integrin-binding protein-2 as a novel gene for pulse wave velocity.

ABSTRACT:

Background

Carotid-femoral pulse wave velocity (PWV) is an important measure of arterial stiffness, which is an independent predictor of cardiovascular morbidity and mortality. In this study, we used an integrated genetic, epigenetic and transcriptomics approach to uncover novel molecular mechanisms contributing to PWV.

Methods and results

We measured PWV in 1505 healthy twins of European descendent. A genomewide association analysis was performed using standardized residual of the inverse of PWV. We identified one single-nucleotide polymorphism (rs7164338) in the calcium and integrin-binding protein-2 (CIB2) gene on chromosome 15q25.1 associated with PWV [β = -0.359, standard error (SE) = 0.07, P = 4.8 × 10]. The same variant was also associated with increased CIB2 expressi

SUBMITTER: Mangino M 

PROVIDER: S-EPMC4845763 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature