Baseline Striatal Functional Connectivity as a Predictor of Response to Antipsychotic Drug Treatment.

ABSTRACT:

Objective

Clinical response to antipsychotic drug treatment is highly variable, yet prognostic biomarkers are lacking. The authors recently demonstrated that successful antipsychotic drug treatment alters resting-state functional connectivity of the striatum. The goal of the present study was to test whether intrinsic striatal connectivity patterns provide prognostic information and can serve as a potential biomarker of treatment response to antipsychotic drugs.

Method

The authors used resting-state functional MRI (fMRI) to develop a prognostic index in a discovery cohort of 41 first-episode schizophrenia patients, then tested this index in an independent cohort of 40 newly hospitalized chronic patients with acute psychosis. In the discovery cohort, patients underwent restin

SUBMITTER: Sarpal DK 

PROVIDER: S-EPMC4845897 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature