Association between two interleukin-2 gene polymorphisms and cancer susceptibility: a meta-analysis.

ABSTRACT:

Background

Several epidemiological studies have illustrated that polymorphisms in interleukin-2 (IL-2) were associated with diverse cancer types. However, recently published statistics were inconsistent and inconclusive. Therefore, the current meta-analysis was performed to elaborate the effects of IL-2 polymorphisms (rs2069762 and rs2069763) on cancer susceptibility.

Material and methods

A total of 5,601 cancer cases and 7,809 controls from 21 published case-control studies were enrolled in our meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association between IL-2 polymorphisms and cancer susceptibility.

Results

Our study demonstrated an increased susceptibility to cancer in rs2069762 (G vs T: OR =1.268, 95% CI =1.1

SUBMITTER: Zhang M 

PROVIDER: S-EPMC4846049 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature