Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.

ABSTRACT:

Purpose

The clinical outcome of multiple myeloma (MM) is heterogeneous. A simple and reliable tool is needed to stratify patients with MM. We combined the International Staging System (ISS) with chromosomal abnormalities (CA) detected by interphase fluorescent in situ hybridization after CD138 plasma cell purification and serum lactate dehydrogenase (LDH) to evaluate their prognostic value in newly diagnosed MM (NDMM).

Patients and methods

Clinical and laboratory data from 4,445 patients with NDMM enrolled onto 11 international trials were pooled together. The K-adaptive partitioning algorithm was used to define the most appropriate subgroups with homogeneous survival.

Results

ISS, CA, and LDH data were simultaneously available in 3,060 of 4,445 patients. We defined t

SUBMITTER: Palumbo A 

PROVIDER: S-EPMC4846284 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature