Molecular evolution of troponin I and a role of its N-terminal extension in nematode locomotion.

ABSTRACT: The troponin complex, composed of troponin T (TnT), troponin I (TnI), and troponin C (TnC), is the major calcium-dependent regulator of muscle contraction, which is present widely in both vertebrates and invertebrates. Little is known about evolutionary aspects of troponin in the animal kingdom. Using a combination of data mining and functional analysis of TnI, we report evidence that an N-terminal extension of TnI is present in most of bilaterian animals as a functionally important domain. Troponin components have been reported in species in most of representative bilaterian phyla. Comparison of TnI sequences shows that the core domains are conserved in all examined TnIs, and that N- and C-terminal extensions are variable among isoforms and species. In particular, N-terminal extensions ar

SUBMITTER: Barnes DE 

PROVIDER: S-EPMC4846289 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature