The Paired-box protein PAX-3 regulates the choice between lateral and ventral epidermal cell fates in C. elegans.

ABSTRACT: The development of the single cell layer skin or hypodermis of Caenorhabditis elegans is an excellent model for understanding cell fate specification and differentiation. Early in C. elegans embryogenesis, six rows of hypodermal cells adopt dorsal, lateral or ventral fates that go on to display distinct behaviors during larval life. Several transcription factors are known that function in specifying these major hypodermal cell fates, but our knowledge of the specification of these cell types is sparse, particularly in the case of the ventral hypodermal cells, which become Vulval Precursor Cells and form the vulval opening in response to extracellular signals. Previously, the gene pvl-4 was identified in a screen for mutants with defects in vulval development. We found by whole genome seque

SUBMITTER: Thompson KW 

PROVIDER: S-EPMC4846358 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature