The Association between Gene-Environment Interactions and Diseases Involving the Human GST Superfamily with SNP Variants.

ABSTRACT: Exposure to environmental hazards has been associated with diseases in humans. The identification of single nucleotide polymorphisms (SNPs) in human populations exposed to different environmental hazards, is vital for detecting the genetic risks of some important human diseases. Several studies in this field have been conducted on glutathione S-transferases (GSTs), a phase II detoxification superfamily, to investigate its role in the occurrence of diseases. Human GSTs consist of cytosolic and microsomal superfamilies that are further divided into subfamilies. Based on scientific search engines and a review of the literature, we have found a large amount of published articles on human GST super- and subfamilies that have greatly assisted in our efforts to examine their role in health and di

SUBMITTER: Hollman AL 

PROVIDER: S-EPMC4847041 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature