Dynamics of the fecal microbiome in patients with recurrent and nonrecurrent Clostridium difficile infection.

ABSTRACT:

Background

Recurrent Clostridium difficile infection (CDI) remains problematic, with up to 30 % of individuals diagnosed with primary CDI experiencing at least one episode of recurrence. The success of microbial-based therapeutics, such as fecal microbiota transplantation, for the treatment of recurrent CDI underscores the importance of restoring the microbiota. However, few studies have looked at the microbial factors that contribute to the development of recurrent disease. Here we compare microbial changes over time in patients with or without recurrence to identify microbial signatures associated with the development of recurrence.

Methods

We used 16S rRNA-encoding gene sequence analysis to compare the fecal microbiota of 93 patients with recurrent and nonrecurrent CDI, s

SUBMITTER: Seekatz AM 

PROVIDER: S-EPMC4847246 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature