Germ stem cells are active in postnatal mouse ovary under physiological conditions.

ABSTRACT:

Study hypothesis

Are active ovarian germ stem cells present in postnatal mouse ovaries under physiological conditions?

Study finding

Active ovarian germ stem cells exist and function in adult mouse ovaries under physiological conditions.

What is known already

In vitro studies suggested the existence of germ stem cells in postnatal ovaries of mouse, pig and human. However, in vivo studies provided evidence against the existence of active germ stem cells in postnatal mouse ovaries. Thus, it remains controversial whether such germ stem cells really exist and function in vivo in postnatal mammalian ovaries.

Study design, samples/materials, methods

Octamer-binding transcription factor 4 (Oct4)-MerCreMer transgenic mice were crossed with R26R-enhanced yellow fluoresc

SUBMITTER: Guo K 

PROVIDER: S-EPMC4847614 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature