Lamivudine Concentration in Hair and Prediction of Virologic Failure and Drug Resistance among HIV Patients Receiving Free ART in China.

ABSTRACT:

Background

The assessment of adherence to antiretroviral therapy (ART) is important in order to predict treatment outcomes. Lamivudine (3TC) is one of the most widely used NRTIs in China, but its concentrations in hair and association with virologic failure and drug resistance have not been studied.

Methods

We conducted a cross-sectional survey to investigate 3TC concentrations in hair as a predictor of virologic failure and drug resistance among HIV patients receiving free ART. We also compared the capacity of hair 3TC concentrations with self-reported adherence in predicting virologic responses. Hair 3TC concentrations were detected through the LC-MS/MS system.

Results

In patients without HIV drug resistance (HIVDR), with a threshold hair 3TC concentration of 260 ng

SUBMITTER: Yan J 

PROVIDER: S-EPMC4847920 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature